I have recently figured out a way how to really optimize CTR on some of my MFA (made for ad-sense) type of websites. The dilemma I have know if I should these techniques on my other websites that have loyal community. How much will invasive advertising turn off my users where I will lose money long term and decrease the value of my ports? Thanks a question worth a lot of money to me now...
On the other hand media websites for example do have many ads all over, but I think it is kind of expected that an online magazine will have many ads, but how much can you pollute someones profile page with ads before they get turned off?